Bruno Canino has performed in major concert halls and festivals in Europe, America, Australia and Asia. For sixty years he has played in a piano duo with Antonio Ballista and for thirty years was member of the Trio di Milano. He has collaborated with distinguished performers as Gazzelloni, Cathy Berberian, Accardo, Amoyal, Nicolet, Vittora Mullova, Itzhak Perlmann and Uto Ughi; and with the Amadeus Quartet, Borodin, Tokyo String Quartet and others.

From 1999-2002 he served as Director of the Music Section of the Venice Biennale, having dedicated particular attention on contemporary music:
He worked with Dallapiccola, Boulez, Berio, Ligeti, Maderna, Stockhausen and Bussotti.
He performed with conductors such as Abbado, Muti, Chailly, Sawallisch, Pappano with orchestras such as La Scala Philarmonic, Santa Cecilia, Berlin Philharmonic, New York Philharmonic, Philadelphia Orchestra, Orchestre National de Paris.
He has made numerous recordings (Debussy, Casella, Mozart, Chabrier, Bach, etc.).
He has given master classes in Italy, Germany, Japan, Spain, and for the last thirty-five years has been invited to the Marlboro Music Festival in Vermont.
His book Handbook of the chamber pianist was followed in 2015 by a book entitled No Music, also published by Passigli.