Francesco Gesualdi has made a name for himself among European critics as one of the most original Italian accordionists engaged in the development and interpretation of contemporary works for the accordion.

He works closely with many of today's foremost composers, and has built up a wide repertoire as soloist and as chamber musician. He has made more than one hundred performance editions - including world premiere and unreleased recordings - of original compositions for accordion by many international authors of today's music scene. He has also worked very closely with Sofia Gubaidulina, Mauricio Kagel, Toshio Hosokawa, Wolfgang Rihm, Alessandro Solbiati, Stefano Gervasoni, Matteo Franceschini, Mauro Cardi, Rebecca Saunders, Howard Skempton, Mauricio Sotelo (just to name a few), playng their most important works for accordion (as soloist and as a chamber musician in various instrumental ensemble), some in Italian premiere, others in world premiere. The focus of many of his concerts in Italy, Europe, Australia and America is characterized by ancient music programs (He has written and played trascriptions of works by early composers such C.Gesualdo, A.de Cabezon, G.Frescobaldi, J.S.Bach, D.Scarlatti) and contemporary music programs. He has performed in the following venues: Sala Santa Cecilia in Rome; Teatro Dal Verme in Milan; Teatro San Carlo in Naples; Teatro del Maggio Musicale Fiorentino in Florence; Associazione Musicale Lucchese; Festival Nuova Consonanza in Rome; Festival Tempo Reale in Florence; Settembre Musica in Turin; Sala Petrassi e Sala Sinopoli at the Auditorium in Rome; Teatro della Pergola - Amici della Musica di Firenze in Florence; Amici della Musica in Ancona; Associazione Musicale Etnea; Fabbrica Europa Festival; Amici della Musica di Modena; Teatro Goldoni in Florence; Auditorium NGV in Melbourne; Auditorium in Milan; Biennale in Venice; Pietà de i Turchini in Naples; Salone Chigi Saraceni at the Accademia Chigiana in Siena; Auditorium Melotti in Rovereto; Auditorium San Fedele in Milan; Radio Rai3; Radio SBS in Melbourne; Radio Vaticana; Radio Orff in Vienna.
He has also played with many eminent ensembles, instrumentalists and director, including the Orchestra Haydn in Bolzano conducted by Marco Angius, Orchestra dei Pomeriggi Musicali in Milan conducted by Rani Calderon; with the violinists Mieko Kanno and Cristiano Rossi; the cellists Francesco Dillon e Alexander Ivashkin; the flautist Roberto Fabbriciani (with whom he has a stable Duo); pianists Matteo Fossi e Gregorio Nardi; singers Alda Caiello, Laura Catrani, Maurizio Leoni, Sonia Bergamasco; actors Carlo Cecchi, Maya Sansa; the Quartetto Savinio; ensembles as Divertimento Ensemble in Milan conducted by Sandro Gorli, Sentieri Selvaggi in Milan conducted by Carlo Boccadoro, Freon Ensemble in Rome conducted by Stefano Cardi, PMCEnsemble at the Auditorium in Rome conducted by Antonio Battista. He has also worked with important centre about electronic music as ExperimentalstudioSWR in Freiburg, Centro Tempo Reale in Florence, Centro ZKM in Karlsruhe. Since 2011 He has been artistic director of the Festival G.A.M.O. in Florence, one of the first contemporary music festivals in Italy and He’s musical director of Gamo Ensemble, ensemble in G.A.M.O. Festival’s residence. In 2010 He founded the RowsEnsemble (accordion quintet). He has recorded with various label: Brillant classics, EMA Vonci, Ars Publica, Stradivarius. He teaches accordion at Conservatoire in Naples (Italy) San Pietro a Majella and accordion at Scuola di Musica di Fiesole.